Changes in version 1.1.3.9000 Changes in version 1.1.3 (2026-05-12) Patch update to update the package maintainer's email address. Changes in version 1.1.2 (2025-11-20) Patch update to the SynergyLMM package (1.1.2) to add the citation to the published article and some minor updates. Fixes - Added citation to published article: https://doi.org/10.1038/s41467-025-65218-9. - APrioriPwr(), PwrSampleSize(), and PwrTime() now allow to control the output of exemplary data plot. - Minor corrections in lmmModel_estimates() documentation and naming of columns in the resulting data frame. Changes in version 1.1.1 (2025-08-22) Patch update to the SynergyLMM package (1.1.1) so it does not break with the new ggplot2 v4.0.0 update. Fixes Replaced fragile test for correct ggplot output in plot_SynergyLMM() function. Changes in version 1.1.0 (2025-07-29) New features: - Gompertz growth model is now available for fitting data using non-linear mixed effect models. - lmmSynergy() now allows for multiple testing correction and p-value adjustment. Breaking changes: - lmmModel_estimates() now also reports the standard error of the fixed effect coefficients. - lmmSynergy() now also returns a data frame with the estimated coefficients, calculated with lmmModel_estimates(), for each time point. - CookDistance() now allows to choose between calculating Cook's distances based on changes of the fitted values, or changes of the fixed effects. Minor improvements and fixes: - Correction of combination index values in lmmSynergy() when method = "RA" and negative values in the denominator appear. A message is prompted and CI values are capped at 100 to maintain interpretability. Changes in version 1.0.1 (2025-02-07) Correcting minor errors in vignette. Changes in version 1.0.0 (2025-02-06) Initial Release We are excited to announce the release of SynergyLMM, an R package providing a comprehensive statistical framework for designing and analyzing in vivo drug combination experiments.