Package: SynergyLMM
Title: Statistical Framework for in Vivo Drug Combination Studies
Version: 1.1.3.9000
Authors@R: 
    c(person("Rafael", "Romero-Becerra", , "rafrombec@gmail.com", role = c("aut", "cre"),
           comment = c(ORCID = "0000-0003-3935-2647")), 
           person("Zhi", "Zhao", email = "zhi.zhao@medisin.uio.no", role = c("ctb")), 
           person("Tero", "Aittokallio", email = "t.a.aittokallio@medisin.uio.no", role = c("ctb")))
Description: A framework for evaluating drug combination effects in
        preclinical in vivo studies. 'SynergyLMM' provides functions to
        analyze longitudinal tumor growth experiments using
        mixed-effects models, perform time-resolved analyses of synergy
        and antagonism, evaluate model diagnostics and performance, and
        assess both post-hoc and a priori statistical power. The
        calculation of drug combination synergy follows the statistical
        framework provided by Demidenko and Miller (2019,
        <doi:10.1371/journal.pone.0224137>). The implementation and
        analysis of linear mixed-effect models is based on the methods
        described by Pinheiro and Bates (2000, <doi:10.1007/b98882>),
        and Gałecki and Burzykowski (2013,
        <doi:10.1007/978-1-4614-3900-4>).
License: GPL (>= 3)
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
Imports: magrittr (>= 2.0.3), rlang, dplyr (>= 1.1.4), ggplot2 (>=
        3.5.1), cowplot (>= 1.1.3), nlme (>= 3.1-165), nlmeU, fBasics,
        car, MASS, performance, lattice, marginaleffects, clubSandwich
Suggests: lme4, knitr, rmarkdown, testthat (>= 3.0.0)
Config/testthat/edition: 3
Depends: R (>= 4.0)
LazyData: true
VignetteBuilder: knitr
URL: https://github.com/RafRomB/SynergyLMM
BugReports: https://github.com/RafRomB/SynergyLMM/issues
Config/roxygen2/version: 8.0.0
Config/pak/sysreqs: cmake make libicu-dev
Repository: https://rafromb.r-universe.dev
Date/Publication: 2026-05-21 14:44:13 UTC
RemoteUrl: https://github.com/rafromb/synergylmm
RemoteRef: HEAD
RemoteSha: 2b3f7f30698fd782346170dc96a689d8b84e9070
NeedsCompilation: no
Packaged: 2026-06-20 06:08:00 UTC; root
Author: Rafael Romero-Becerra [aut, cre] (ORCID:
    <https://orcid.org/0000-0003-3935-2647>),
  Zhi Zhao [ctb],
  Tero Aittokallio [ctb]
Maintainer: Rafael Romero-Becerra <rafrombec@gmail.com>